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Like muscle and bone, ligaments are dynamic, undergoing hypertrophy with physical exercise and atrophy with immobilization. This paper reviews the structure and composition of ligaments and discusses the cellular events accountable for atrophy of ligaments with immobilization. As an experimental model, one knee of New Zealand White rabbits was immobilized with a pin. After two, 4, and 8 weeks of immobility, the medial collateral ligaments were isolated and enzyme evaluation was performed.
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